A team of researchers have successfully identified gene mutations that are seen to control the epigenetic regulation.
These genes are believed to have a greater role in contributing to autism and schizophrenia.
Schizophrenia is seen to affect a greater number of adults and is a condition that can be diagnosed by analyzing the symptoms duration and observing behavior. There is no clear biological understanding of schizophrenia and this is one of the many reasons that are seen to hinder the development of accurate diagnosis resulting in lesser-effective treatments.
The disorder is observed to be inheritable and due to vast improvements in genomic technologies, a greater emphasis is placed on the genetic risk factors that attribute to the condition.
Earlier researches in these areas have provided rough estimates for about quarter genetic contributions being directly related to the risk of Schizophrenia.
Some error has occured.
Further, it has been revealed genetic risks overlap with similar psychiatric orders, for instance; bipolar disorder.
Earlier researches have also found an existing link between genetic variants that are supposedly implicated in ASD, seizure disorder, schizophrenia and intellectual disability.
To have the link further explored, a team of researchers from the Trinity College in Dublin and Cold Spring Harbor Laboratories, New York performed a genetic sequence on a group of 171 people.
These people had at least one family member who had been diagnosed with Schizophrenia.
While performing sequence analysis, the young team of researchers identified a new genetic mutation that was seen to be present in individuals affected by Schizophrenia. Interestingly, these mutations were seen not to be present in their parents. This shows the mutation present were new and were not inherited.
Shane McCarthy, the first author of the study, says “These mutations were seen to occur more often than expected in individuals with schizophrenia.” The author further explains, “These mutations are seen to likely have other functional consequences.”
Professor Aiden Corvin, senior author from the Trinity College explains, “At times these things happen and every one of us is likely to have a negligible number of damaging mutations, however; with no serious health consequences.”
Professor Corvin further says, “In this particular study, two things were of prime interest:”
First, the happenings were already seen to have been implicated in intellectual disabilities and autism.
Second, the genes were seen to be greatly involved in the similar process.
The professor further explains, “To understand with better accuracy, we ran a test to understand if this could be a chance clustering. However, it was not the case.”
This means that the analyzed genes are seen to have a commonly occurring condition known as chromatin condition which is responsible for regulating other genetic functions.
Professor Corvin says he believes chromatin modification to be an important and a critical molecular mechanism that is required to explain the emergence of developmental disorders.
“These findings are exciting as they point towards neurodevelopmental disorders like autism and schizophrenia to have common underlying mechanisms which could provide implications in future studies giving rise to better treatments,” explains Prof. Corvin while signing off.